DIVANEX ER-250/ER-500/ER-750/ER-1000 (DIVALPROEX SODIUM TABLETS)

DESCRIPTION

Divalproex sodium is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxide. Chemically it is designated as sodium hydrogen bis(2-propylpentanoate). Divalproex sodium has the following structure:

DOSAGE

Initial Therapy: 10 to 15 mg/kg/day. Titration: Increase by 5 to 10 mg/kg/week to achieve optimal clinical response. Maintenance: Usually below 60 mg/kg/day. No recommendation regarding safety at doses above 60 mg/kg/day can be made.

CLINICAL PHARMACOLOGY

Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. It has been suggested that its activity in epilepsy is related to increased brain concentrations of gamma-aminobutyric acid (GABA).

INDICATIONS

A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas.

CONTRA INDICATIONS

Divalproex should not be administered to patients with hepatic disease or significant hepatic dysfunction. Divalproex is contraindicated in patients with known hypersensitivity to the drug. Divalproex is contraindicated in patients with known urea cycle disorders. Divalproex is contraindicated for use in prophylaxis of migraine headaches in pregnant women

SIDE EFFECTS

confusion, tiredness, cold feeling, vomiting, change in your mental state, easy bruising, unusual bleeding (nose, mouth, or gums), purple or red pinpoint spots under your skin, severe drowsiness, worsening seizures, mild nausea or vomiting, mild stomach pain, diarrhea, headache, mild dizziness, weakness, tremors, problems with balance or walking, blurred vision, double vision or changes in appetite, weight gain.

DRUG INTERACTIONS

Liver Disease, Mental Retardation, Metabolic Disorder – Congenital, Brain Anomalies – Congenital.

AVAILABILITY

 Divalproex sodium is available in strips  of  ten  capsules containing Divalproex sodium Capsules.

About us

NEXT LABS, a name that that signifies the state of well-being is dedicated to promoting healthcare for more than a decade and provides high quality products for customers focused on healthcare and diseases. Since its inception, NEXT has been on a quest to sustain and improve the quality of life with the ultimate purpose of making the world a healthier place.