HALONEX-5 (HALOPERIDOL TABLETS)

DESCRIPTION

Haloperidol tablets are an antipsychotic agent. Exactly how it works is not known, but it may work by blocking certain chemicals in the brain.

DOSAGE

Initial dose: 0.5 to 5 mg orally 2 to 3 times a day. Maintenance dose: 1 to 30 mg/day in 2 or 3 divided doses. Infrequently, haloperidol has been used in doses above 100 mg for severely resistant patients.

CLINICAL PHARMACOLOGY

Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D2 receptor antagonism and slow receptor dissociation kinetics. It has effects similar to the phenothiazines. The drug binds preferentially to D2 and Alpha 1 receptors at low dose (ED50 = 0.13 and 0.42 mg/kg, respectively), and 5-HT2 receptors at a higher dose (ED50 = 2.6 mg/kg).

INDICATIONS

Tourette’s disorder. For severe behavior disorders or as a short-term treatment for hyperactivity in children who are refractory to psychotherapy or other medications.

CONTRA INDICATIONS

Pre-existing coma, acute stroke.Severe intoxication with alcohol or other central depressant drugs.Known allergy against haloperidol or other butyrophenones or other drug ingredients.Known heart disease, when combined will tend towards cardiac arrest

SIDE EFFECTS

Dystonia, Muscle rigidity, Akathisia, Parkinsonism, Hypotension, Constipation, Dry mouth, Blurred vision, Somnolence.

DRUG INTERACTIONS

Other central depressants (alcohol, tranquilizers, narcotics): actions and side effects of these drugs (sedation, respiratory depression) are increased. In particular, the doses of concomitantly used opioids for chronic pain can be reduced by 50%. Methyldopa: increased risk of extrapyramidal side effects and other unwanted central effects, Levodopa: decreased action of levodopa, Tricyclic antidepressants: metabolism and elimination of tricyclics significantly decreased, increased toxicity noted (anticholinergic and cardiovascular side effects, lowering of seizure threshold), Lithium: rare cases of the following symptoms have been noted: encephalopathy, early and late extrapyramidal side effects.

AVAILABILITY

 HALONEX-5is available in strips  of  ten  capsules containing HALOPERIDOL TABLETS Capsules.