NEXLOR-1/2 (Lorazepam 1/2 mg Tablets)

DESCRIPTION

Lorazepam provides prompt relief from a variety of  symptoms associated with anxiety and in anxiety associated with depression.

DOSAGE

Generally 2-3 mg daily and maximum 10mg daily. The drug should be given in divided doses.

CLINICAL PHARMACOLOGY

Lorazepam presumably exert its effect by binding to specific receptors at several sites within the central nervous system either by potentiating the effects of synaptic or presynaptic inhibition mediated by gama-aminobutyric acid or by directly affecting the action potential generating mechanisms.

INDICATIONS

Anxiety disorders, anxiety associated with depressive symptoms. Anxiety component in psychotic states. Pre-surgical medication.

CONTRA INDICATIONS

Hypersensitivity to benzodiazepines.

PRECAUTIONS

Acute narrow angle glaucoma, renal or hepatic impairment, periodic blood counts & liver function tests in prolong therapy.

SIDE EFFECTS

Sedation followed by dizziness, weakness & unsteadiness. Disorientation, depression, nausea, change in appetite, headache, sleep disturbance.

DRUG INTERACTIONS

Potentiation  of  CNS depression produced by alcohol, general anaesthetics, narcotic analgesics, tricyclic antidepressants and MAOIs.

OVER DOSAGE

Emesis, gastric lavage, sedation and depression.

AVAILABILITY

NEXLOR is available in strips of ten  uncoated tablets containing Lorazepam BP 1/2mg.