PARONEX-20/CR-12.5/25/37.5 (QUETIAPINE TABLETS)

DESCRIPTION

Treating schizophrenia or bipolar disorder. It may also be used for other conditions as determined by your doctor. Quetiapine is an atypical antipsychotic. Exactly how it works is not known. It is thought to affect certain substances in the brain.

DOSAGE

The dosage may be increased in increments of 25 to 50 mg two times a day or three times a day on the second and third days (as tolerated). By the fourth day a dosage range of 300 mg to 400 mg daily (divided into 2 or 3 doses a day) may be achieved. Additional dosage adjustments (increases or decreases) of 25 to 50 mg twice a day may be made, as needed. However, at least 2 days should pass between the additional dosage adjustments.

CLINICAL PHARMACOLOGY

The mechanism of action of SEROQUEL is unknown. However, it has been proposed that the efficacy of SEROQUEL (Quetiapine ) in schizophrenia and its mood stabilizing properties in bipolar depression and mania are mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other effects of SEROQUEL.

INDICATIONS

Quetiapine   is indicated for the treatment of schizophrenia. The efficacy of Quetiapine  in schizophrenia was established in three 6-week trials in adults and one 6-week trial in adolescents (13-17 years). The effectiveness of Quetiapine  for the maintenance treatment of schizophrenia has not been systematically evaluated in controlled clinical trials

CONTRA INDICATIONS

Hypersensitivity to quetiapine or to any excipients in the SEROQUEL formulation. Anaphylactic reactions have been reported in patients treated with SEROQUEL(Quetiapine).

SIDE EFFECTS

Chills, cold sweats, confusion, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, sleepiness or unusual drowsiness, Less common, Black, tarry stools, blurred vision, changes in patterns and rhythms of speech, chest pain, cough ,drooling, fever, muscle aches, or sore throat, inability to move the eyes, inability to sit still

DRUG INTERACTIONS

Quetiapine exposure is increased by the prototype CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, indinavir, ritonavir, nefazodone, etc.) and decreased by the prototype CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampin, avasimibe, St. John’s wort etc.). Dose adjustment of quetiapine will be necessary if it is co-administered with potent CYP3A4 inducers or inhibitors.

AVAILABILITY

QUTANEX SR-200/SR-400/SR-50/SR-100 is available in strips  of  ten  capsules containing QUETIAPINE TABLETS.